Skies Above the Reich is a solitaire game depicting a Luftwaffe squadron of Bf109s struggling to deter and destroy the relentless daylight raids over Germany during World War Two. The player's individual aircraft, each represented by a stickered block, must confront the mighty "combat box" formation of the United States Army Air Force, a deadly terrain of B-17 Flying Fortresses.

The game is a broad strokes depiction that presents the arc of the desperate air war. Stretching from late 1942 to early 1945, Skies Above the Reich follows that trajectory in a series of missions strung together to make a campaign. Each mission will take a half hour or more to play, while a campaign can last anywhere from six to sixty missions